HuBMAP BodyThe Human Reference Atlas: High-Resolution, Functional Mapping of Voxel, Vector, and Meta Datasets
MC-IU team within the HuBMAP HIVE

The ultimate goal of the HIVE Mapping effort is to develop a common coordinate framework (CCF) for the healthy human body. This framework will support cataloging different types of individual cells, understanding the functions of and relationships between those cell types, and modeling their individual and collective function. During the initial three years of HuBMAP, the MC-IU team has built many elements of the CCF. We co-organized the construction of ASCT+B Tables and implemented a CCF Ontology. We collaborated with NIAID at NIH on the design of a 3D Reference Object Library. Lastly, we developed three interactive user interfaces. The CCF ASCT+B Reporter supports the authoring and interactive review of ASCT+B Tables. The CCF Registration User Interface (RUI) supports uniform tissue data registration across organs and labs. The CCF Exploration User Interface (EUI) supports exploration of semantically and spatially explicit data—from the whole body to the single cell level. For an introduction to HuBMAP goals, data, and code visit the Visible Human MOOC (VHMOOC).




We deeply value close collaborations with the HuBMAP TMCs and other HIVE teams. This research has been funded in part by the NIH Common Fund OTA 20-005 under award OT2 OD030545 and through the Office of Strategic Coordination/Office of the NIH Director under award OT2OD026671, by the NIDDK Kidney Precision Medicine Project grant U2CDK114886, and the NIH NIAID, Department of Health and Human Services under BCBB Support Services Contract HHSN316201300006W/HHSN27200002. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the NIH.